Ludewa District is one of six districts in the Njombe Region in Tanzania, East Africa. Prior to 2012, the district was one of the seven districts of Iringa Region. The town of Ludewa is the administrative seat of the district. A hospital is located in the city. The district is bordered to the north by the Njombe Rural District and Makete District, to the southeast by the Ruvuma Region and to the southwest by the country of Malawi across Lake Nyasa.

In 2016 the Tanzania National Bureau of Statistics report there were 137,520 people in the district, from 133,218 in 2012.