Nyang’hwale District is one of the five districts of Geita Region of Tanzania. Its administrative centre is the village Kharumwa. It is bordered to the north by Sengerema District, to the east by Misungwi District and Shinyanga Rural District, to the south by Kahama Rural District, and to the west by Geita District.

As of 2022, the population of Nyang’hwale was 225,803. Nyang’hwale was established in 2012, when it was split off from Geita District and became part of the newly established Geita Region.